Novel mechanisms for cleavage-independent activation of gasdermins revealed
Phys.org -

Pyroptosis is a type of programmed cell death mediated by the gasdermin (GSDM) protein family, which plays important roles in the body's defense against pathogen infection, elimination of abnormal or harmful cells, and other processes. GSDMs are an evolutionarily conserved class of pore-forming proteins that are widely distributed among various bacteria, fungi, invertebrates, and all vertebrates.

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